Protein Homeostasis Diseases
Mechanisms and Novel TherapiesProtein Homeostasis Diseases: Mechanisms and Novel Therapies offers an interdisciplinary examination of the fundamental aspects, biochemistry and molecular biology of protein homeostasis disease, including the use of natural and pharmacological small molecules to treat common and rare protein homeostasis disorders. Contributions from international experts discuss the biochemical and genetic components of protein homeostasis disorders, the mechanisms by which genetic variants may cause loss-of-function and gain-of-toxic-function, and how natural ligands can restore protein function and homeostasis in genetic diseases. Applied chapters provide guidance on employing high throughput sequencing and screening methodologies to develop pharmacological chaperones and repurpose approved drugs to treat protein homeostasis disorders.Provides an interdisciplinary examination of protein homeostasis disorders, with an emphasis on treatment strategies employing small natural and pharmacological ligandsOffers applied approaches in employing high throughput sequencing and screening to develop pharmacological chaperones to treat protein homeostasis diseaseGathers expertise from a range of international chapter authors who work across various biological methods and disease specific disciplines of relevance ISBN: 9780128191323, 0128191325
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